2 edition of Cholesterol, bile acids and atherosclerosis found in the catalog.
Cholesterol, bile acids and atherosclerosis
Herman van Belle
|Statement||Herman van Belle.|
|The Physical Object|
|Number of Pages||159|
Cholesterol returned to the liver by HDL is synthesized into bile acids. Bile acids facilitate the digestion of lipids by acting as emulsifying agents and also aid in the absorption of fat-soluble vitamins. Cholesterol is ultimately excreted from the body as bile acids. Excessive levels of oxidized LDL in the blood can lead to potential health. The addition of LF to a HCD significantly increased fecal neutral steroids levels (22% increase, p cholesterol levels (17% decrease, p cholesterol excretion via interactions with bile by: 7.
Blocking intestinal absorption of bile acids at the apical versus basolateral membrane differentially affects bile acid and cholesterol metabolism, including the development of hypercholesterolemia-associated atherosclerosis. The molecular mechanism likely involves altered regulation of Cited by: 8. The use of probiotics, alone or in interaction with bile acids, is a modern strategy in the prevention and treatment of hypercholesterolemia. Numerous mechanisms for .
Farnesoid X Receptor Activation Increases Reverse Cholesterol Transport by Modulating Bile Acid Composition and Cholesterol Absorption in Mice Yang Xu,1 Fei Li, 2Munaf Zalzala,1,3 Jiesi Xu, 1Frank J. Gonzalez, Luciano Adorini,4 Yoon-Kwang Lee, Liya Yin, and Yanqiao Zhang1 Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal by: bile acid sequestrants -- cholestyramine (locholest, prevalite, questran), colestipol (colestid), colesevelam (welchol) -- bind to bile acids in the intestines. this leads to a lower bile acid level.
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Background: Excess cholesterol is usually eliminated from the body by conversion to bile acids excreted in feces as bile salts. The excretion of large amounts of bile protects against atherosclerosis, while diminished excretion may lead to coronary artery disease (CAD).Cited by: Van Belle deals specifically with the metabolic relations of cholesterol with the bile acids, and in his review he has bile acids and atherosclerosis book over references.
In fact, atherosclerosis is only a side issue, and the emphasis of the book is on the chemistry and metabolism of the bile by: 1. The rate of degradation of cholesterol to bile acids is regulated by the amount of bile acids returning to the liver in the portal vein.
It is thus evident that disturbances of bile acid metabolism may have profound effects on the whole-body cholesterol balance and on lipoprotein : B. Angelin. Hormones and Atherosclerosis covers the proceedings of the conference held in Brighton, Utah on MarchThe book focuses on the role of hormones in atherosclerosis, as well as cholesterol metabolism and biosynthesis, lipogenesis, and lipid transport.
The book focuses on the role of hormones in atherosclerosis, as well as cholesterol metabolism and biosynthesis, lipogenesis, and lipid transport. The selection first discusses the biosynthesis of cholesterol and aspects of the biosynthesis of cholesterol from mevalonic Edition: 1.
Cholesterol andLipoproteinMetabolism Atherosclerosis., ; 16 (Suppl. 1): ss42 29 secretion of cholesterol and bile acids into bile, reduces plasma cholesterol concentrations and helps to remove excess amounts of cholesterol from the body.
Figure 1 il-lustrates the general features of cholesterol balance across the body. Cholesterol is an unsaturated alcohol of the steroid family of compounds; it is essential for the normal function of all animal cells and is a fundamental element of their cell membranes. It is also a precursor of various critical bile acids and atherosclerosis book such as adrenal and gonadal steroid hormones and bile by: Full Text; PDF ( K) PDF-Plus ( K) Citing articles; Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats 1.
Kanae Nakamura, a Satoru Morishita, a b Tomoji Ono, a c Michiaki Murakoshi, a c d Keikichi Sugiyama, a e Hisanori Kato, b Ikuo Ikeda, f Hoyoku Nishino d a Research and Development Headquarters, Lion Corporation, Tajima, Odawara, Kanagawa Cited by: 7.
Abstract. We determine the effects of alfalfa top saponins on cholesterol and bile acid balance in eight cynomolgus macaques (Macaca fascicularis). The monkeys ate semipurified food containing cholesterol with or without added saponins.
The saponins decreased cholesterolemia without changing the levels of high density lipoprotein-cholesterol; hence, Cited by: Bile acid synthesis is a major pathway for hepatic cholesterol catabolism.
Bile acid synthesis generates bile flow which is important for biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics. Bile acids are biological detergents that facilitate intestinal absorption of lipids and fat-soluble by: Cholesterol Down: Ten Simple Steps to Lower Your Cholesterol in Four Weeks--Without Prescription Drugs Paperback – Decem by Janet Brill (Author) out of 5 stars ratings.
See all 5 formats and editions. Hide other formats and editions. Audible Audiobook, Unabridged. Unknown Binding. $ Read with Our Free App/5(). Free cholesterol is removed from tissues by plasma high-density lipoprotein (HDL) and transported to the liver, where it is eliminated from the body either unchanged or after conversion to bile acids in the process known as reverse cholesterol transport (see Chapter 25).
Cholesterol is a. The liver may now excrete the cholesterol into bile (either unchanged or as bile acids), incorporate it into membranes, or resecrete it into plasma as lipoprotein cholesterol.
Endogenous Lipid Transport: The VLDL-LDL Cycle (Apo B System) This cycle allows the hepatocyte to export triglycerides and cholesterol to peripheral tissues as VLDL.
A cholesterol-lowering effect can be achieved by reducing cholesterol synthesis or by increasing fecal excretion of bile acids (ileal sodium-dependent bile acid transporter inhibitors). It is important to emphasize that the ability to excrete large amounts of bile acids not only prevents CAD development but also may also prevent atherosclerosis Cited by: Cholesterol is present in tissues and in plasma either as free cholesterol or combined with a long-chain fatty acid as cholesteryl ester, the storage form.
In plasma, both forms are transported in lipoproteins (see Chapter 25).Cholesterol is an amphipathic lipid and as such is an essential structural component of membranes, where it is important for the maintenance of the correct permeability.
Oxysterols play a role in the regulation of cholesterol synthesis, transport and efflux. A scavenger effect of cholesterol hydroxylase on elevated serum cholesterol levels is well demonstrated.
Bile acid synthesis occurs through two main pathways, the classic and the alternative by: During cold stimulation, cholesterol is converted to bile acids in an alternative pathway.
The bile acids then alter the microbiota, which in turn promotes more heat generation. Adaptive Cited by: Bile acids are synthesised from cholesterol by the liver and are the major end products of cholesterol catabolism.
Bile acid homoeostasis is dependent on hepatic de novo synthesis and an intact enterohepatic circulation, by means of which bile acids emptied into the small intestine are efficiently reabsorbed and sent back to the liver for. Additional Physical Format: Online version: Belle, Herman van.
Cholesterol, bile acids, and atherosclerosis. Amsterdam, North-Holland Pub. Co., Cholesterol is also the precursor from which the body synthesizes vitamin D.
One of the major uses of cholesterol is the synthesis of bile acids. These are synthesized in the liver from cholesterol and are secreted in the bile. They are essential for the absorption of fat from the contents of the intestine.
Problems caused by cholesterol. Cholesterol can also create problems. High levels of LDL cholesterol lead to the development of atherosclerosis: cholesterol-rich deposits (plaques) that form on the inside of blood vessels and predispose to heart attacks.; Cholesterol in the bile can crystallize to form gall stones that may block the bile ducts.ISBN: OCLC Number: Description: x, illustrations ; 24 cm.
Contents: Liver, lipoproteins, and atherosclerosis: an overview / Scott M. Grundy --Causes and treatment of hypercholesterolemia / Scott M. Grundy, Gloria Lena Vega and David W. Bilheimer --Bile acids and lipoprotein metabolism / Bo Angelin and Kurt Einarsson --Hyperlipoproteinemia.Atherosclerosis is the leading cause of death in North America and within the next two decades will be the leading cause worldwide.
Atherosclerosis is characterized by vascular obstruction from the deposits of plaque, resulting in reduced blood by: